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Mariana Puntel Selected Research

Thymidine Kinase

3/2014Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models.
5/2013Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
10/2012Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
8/2012Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
6/2010A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
7/2009Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
2/2008Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
7/2007Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
8/2005Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

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Mariana Puntel Research Topics

Disease

11Neoplasms (Cancer)
03/2014 - 08/2005
11Glioma (Gliomas)
05/2013 - 12/2004
8Brain Neoplasms (Brain Tumor)
03/2014 - 12/2004
6Glioblastoma (Glioblastoma Multiforme)
03/2014 - 07/2007
4Herpes Simplex
05/2013 - 08/2005
1Melanoma (Melanoma, Malignant)
03/2014
1Parkinson Disease (Parkinson's Disease)
01/2013
1Neuroinflammatory Diseases
01/2013
1Pain (Aches)
08/2009
1Ganglion Cysts (Ganglion)
08/2009
1Facial Pain (Myofacial Pain)
08/2009
1Hypertrophy
08/2008
1Inflammation (Inflammations)
07/2007
1Pituitary Neoplasms (Pituitary Adenoma)
12/2005

Drug/Important Bio-Agent (IBA)

9Thymidine KinaseIBA
03/2014 - 08/2005
6CytokinesIBA
05/2013 - 06/2010
6flt3 ligand protein (flt3 ligand)IBA
10/2012 - 12/2004
3Ganciclovir (Cytovene)FDA LinkGeneric
03/2014 - 07/2007
3Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
05/2013 - 08/2005
3LigandsIBA
05/2013 - 08/2005
2EnzymesIBA
03/2014 - 07/2007
2Proteins (Proteins, Gene)FDA Link
10/2012 - 07/2009
2Immunotoxins (Immunotoxin)IBA
10/2011 - 06/2011
2Phosphotransferases (Kinase)IBA
06/2010 - 05/2008
1Temozolomide (Temodar)FDA LinkGeneric
03/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2013
1NF-kappa B (NF-kB)IBA
10/2012
1Immunoglobulin G (IgG)IBA
10/2012
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
10/2012
1CD40 Ligand (CD40L)IBA
10/2012
1Chemokine CCL3IBA
10/2012
1Interleukin-12 (IL 12)IBA
10/2012
1ChemokinesIBA
10/2012
1InterferonsIBA
10/2012
1Interleukin-2 (IL2)IBA
10/2012
1Immunoglobulins (Immunoglobulin)IBA
10/2011
1Neoplasm Antigens (Tumor Antigens)IBA
10/2011
1AntibodiesIBA
10/2011
1Cytotoxins (Cytolysins)IBA
11/2010
1Antineoplastic Agents (Antineoplastics)IBA
11/2010
1gamma-Aminobutyric Acid (GABA)IBA
08/2009
1Formaldehyde (Formol)FDA Link
08/2009
1GABA Receptors (GABA Receptor)IBA
08/2009
1Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
08/2009
1Glycyrrhizic Acid (Glycyrrhizin)IBA
07/2009
1HMGB1 Protein (HMG1)IBA
07/2009
1Antiviral Agents (Antivirals)IBA
08/2008
1beta-Galactosidase (Lactaid)IBA
07/2007
1Hormones (Hormone)IBA
12/2005
1Nucleic AcidsIBA
12/2005
1AntigensIBA
12/2004

Therapy/Procedure

13Therapeutics
05/2013 - 12/2004
2Immunotherapy
03/2014 - 10/2012
1Drug Therapy (Chemotherapy)
03/2014
1Aftercare (After-Treatment)
07/2009